Composition: Each 1 ml contains:
Closantel sodium dihydrate……….135.9 mg (Equivalent to closantel 125 mg)
Hepaclosan is a combination of ivermectin and closantel formulated as a solution for injection
used for cattle and sheep. The product is effective against a wide range of internal and external
Ivermectin is an avermectin macrocyclic lactone and acts by inhibiting nerve impulses. It
enhances the release of gamma-aminobutyric acid (GABA) at presynaptic neurons. GABA acts
as an inhibitory neurotransmitter which blocks the post-synaptic stimulation of neuron in
nematodes or muscle fibers in arthropods resulting in paralysis of the parasite and eventual
Closantel is a parasiticide with flukicide activity and efficacy against certain other helminths and
arthropods. Closantel is a member of the salicylanilide group of anthelmintics. It acts by
uncoupling oxidative phosphorylation.
Hepaclosan is indicated for the treatment of the following:
1 ml Hepaclosan per 25 kg B.Wt.
Withdrawal periods :
Meat: 49 days.
Meat: 28 days.
Not to be used in cattle or sheep producing milk for human consumption including pregnant
animals intended to produce milk for human consumption.