Each 1 ml contains:
-Sulphadiazine sodium 218.45 mg
-Trimethoprim 40 mg
Theracanzan Oral Solution is a combination of trimethoprim and sulphadiazine. The action of this combination proved to be bactericidal, whereas the components separately were only bacteriostatic in action.
-Sulfadiazine (SDZ) acts as anti-metabolite by inhibiting the incorporation of para- aminobenzoic acid (PABA) into folic acid.
-Trimethoprim (TMP) inhibits the enzyme dihydrofolate reductase (DHFR) which converts dihydrofolic acid into tetrahydrofolic acid (THFA).
-SDZ/TMP combination is bactericidal, inhibiting sequential steps in the synthesis of purines, which are required for DNA synthesis. This double blockade mode of action leads to broad bactericidal action.
Theracanzan Oral Solution has a strong bactericidal action against a wide range of Gram positive and Gram-negative aerobic bacteria, a large proportion of anaerobic bacteria, Chlamydia and protozoa.
Theracanzan Oral Solution is indicated in the treatment of the following
-Colibacillosis caused by E.coli in broiler chickens, young calves and foals.
-Infectious coryza caused by Haemophilus paragallinarum in broiler chickens.
-Turkey coryza caused by Bordetella avium in turkeys.
-Fowl cholera caused by Pasteurella multocida in broiler chickens.
-Pullorum disease caused by Salmonella pullorum in broiler chickens.
-Fowl typhoid caused by Salmonella gallinarum in broiler chickens.
Calves, foals, broiler chickens and turkeys.
Dosage and administration:
Route of administration: Orally via drinking water.
Calves and Foals: 1ml Theracanzan Oral Solution/8 kg B.wt. for 3-5 days.
Broiler chickens and Turkeys: 10 days.